The effect of stabilizer type (small molecule vs. polymeric) and the amount of micellar solubilized drug on Ostwald ripening of nanosuspensions was investigated. Indomethacin nanosuspensions were prepared with small molecule stabilizers (sodium lauryl sulfate (SLS) and Dowfax 2A1 (DF)) and a polymeric stabilizer (hydroxypropyl methyl cellulose (HPMC)). Two different drug:stabilizer ratios were ...

The well-known alcoholic beverage Pastis becomes turbid when mixed with water due to the poor solubility of trans-anethol, the anise-flavored component of Pastis in the water solution formed. This destabilization appears as the formation of micrometer-sized droplets that only very slowly grow in size, thus expanding the life of the anise-flavored beverage. The slow growth has been attributed to...

We carried out density functional theory calculations to investigate the ripening of Pd clusters on CeO2(111). Starting from stable Pd n clusters (n = 1-21), we compared how these clusters can grow through Ostwald ripening and coalescence. As Pd atoms have mobility higher than that of Pd n clusters on the CeO2(111) surface, Ostwald ripening is predicted to be the dominant sintering mechanism. P...

We introduce an agent-based model for advection-mediated chiral autocatalysis in which we take into account dissolution-crystallization processes through Ostwald ripening. We demonstrate that the latter phenomenon is the key to explaining previously puzzling experimental results whereby complete chiral symmetry breaking is attained from an initially unbiased mixture of seed crystals. We show th...

The stability of foams (and of aerated systems in general) is affected by three basic mechanisms: drainage, Ostwald ripening (also called disproportionation), and coalescence. Ostwald ripening, in particular, refers to the changes in bubble size due to gas diffusion driven by local differences in Laplace pressure, or by gas diffusion to a head space. This process can be strongly influenced by t...

Curcumin is a flavonoid found in the rhizome of the turmeric plant (Curcuma longa L.) and has recently attracted interest because it has numerous biological functions and therapeutic properties. In the present study, we attempted to incorporate curcumin into medium-chain triglyceride (MCT) nanoemulsions (0.15 wt% curcumin, 10 wt% MCT oil, and 10 wt% emulsifiers) with various emulsifiers [polyox...

Ostwald ripening and chemotaxis are two different mechanisms that describe particle motion throughout a domain. Ostwald ripening describes the redistribution of a solid solution due to energy potentials while chemotaxis is a cellular phenomenon where organisms move based on the presence of chemical gradients in their environment. Despite the two systems coming from disparate fields, they are co...

This paper reports level set simulations of the Ostwald ripening of two-dimensional homoepitaxial islands. The simulation accurately accounts for both adatom diffusion between the islands and adatom attachment/detachment processes at the island edges. We compute the time evolution of the average island size and the full island size distribution function. The results provide support for a previo...

The physical basis behind the Ostwald ripening process for two-phase mixture has been reviewed in detail, using the various theories developed to describe this process. The Ostwald ripening, also termed second phase coarsening, is generally thought to be slow, diffusion-controlled process which occurs subsequent to phase separation under extremely small under-saturation levels. The major advanc...